Open AccessPentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes
Author(s) -
David F. Bruhn,
Susan Wyllie,
Adaris Rodríguez-Cortés,
Angela K. Carrillo,
Rakesh Rakesh,
R. Kiplin Guy,
Alan H. Fairlamb,
Richard Lee
Publication year - 2015
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkv417
Subject(s) - nifurtimox , nitrofuran , virology , microbiology and biotechnology , biology , parasite hosting , trypanosoma cruzi , world wide web , computer science , genetics
In response to reports of Trypanosoma brucei resistance to the nitroaromatic drug nifurtimox, we evaluated the potential of antituberculosis nitrofuran isoxazolines as inhibitors of trypanosome growth.
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