Impact of food on the pharmacokinetics of first-line anti-TB drugs in treatment-naive TB patients: a randomized cross-over trial | Zendy

Antonia Morita Iswari Saktiawati | Zendy; Marieke G. G. Sturkenboom | Zendy; Ymkje Stienstra | Zendy; Yanri Wijayanti Subronto | Zendy; Sumardi Sumardi | Zendy; Jos G.W. Kosterink | Zendy; Tjip S. van der Werf | Zendy; JanWillem C. Alffenaar | Zendy

Open Access

Impact of food on the pharmacokinetics of first-line anti-TB drugs in treatment-naive TB patients: a randomized cross-over trial

Author(s) -

Antonia Morita Iswari Saktiawati,

Marieke G. G. Sturkenboom,

Ymkje Stienstra,

Yanri Wijayanti Subronto,

Sumardi Sumardi,

Jos G.W. Kosterink,

Tjip S. van der Werf,

JanWillem C. Alffenaar

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv394

Subject(s) - pyrazinamide , ethambutol , isoniazid , rifampicin , pharmacokinetics , medicine , bioavailability , pharmacology , tuberculosis , pathology

Concomitant food intake influences pharmacokinetics of first-line anti-TB drugs in healthy volunteers. However, in treatment-naive TB patients who are starting with drug treatment, data on the influence of food intake on the pharmacokinetics are absent. This study aimed to quantify the influence of food on the pharmacokinetics of isoniazid, rifampicin, ethambutol and pyrazinamide in TB patients starting anti-TB treatment.

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