Horizontal gene transmission of thecfrgene to MRSA andEnterococcus: role ofStaphylococcus epidermidisas a reservoir and alternative pathway for the spread of linezolid resistance | Zendy

Fabio Cafini | Zendy; Le Thuy Thi Nguyen | Zendy; Masato Higashide | Zendy; Federico Román | Zendy; J. Prieto | Zendy; Kazuya Morikawa | Zendy

Open Access

Horizontal gene transmission of thecfrgene to MRSA andEnterococcus: role ofStaphylococcus epidermidisas a reservoir and alternative pathway for the spread of linezolid resistance

Author(s) -

Fabio Cafini,

Le Thuy Thi Nguyen,

Masato Higashide,

Federico Román,

J. Prieto,

Kazuya Morikawa

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv391

Subject(s) - linezolid , plasmid , microbiology and biotechnology , enterococcus , staphylococcus epidermidis , biology , transmission (telecommunications) , methicillin resistant staphylococcus aureus , staphylococcus aureus , horizontal gene transfer , virology , gene , antibiotics , genetics , bacteria , vancomycin , genome , electrical engineering , engineering

Linezolid resistance mediated by the cfr gene represents a global concern due to its dissemination among multiresistant nosocomial pathogens such as MRSA and Enterococcus. In the present work, we have evaluated the in vitro transmission of cfr pSCFS7-like plasmids from two Staphylococcus epidermidis ST2 strains (SE45 and SE50) isolated in Spanish hospitals, to clinical MRSA and Enterococcus spp. isolates obtained in Japan, a country in which cfr has not been detected yet. We have also investigated alternative mechanisms of horizontal gene transfer involved in the spread of the cfr gene.

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