Evaluation of CTX-M steady-state mRNA, mRNA half-life and protein production in various STs ofEscherichia coli | Zendy

Chelsie N. Geyer | Zendy; Randal C. Fowler | Zendy; James R. Johnson | Zendy; Brian Johnston | Zendy; Scott J. Weissman | Zendy; Peter M. Hawkey | Zendy; Nancy D. Hanson | Zendy

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Evaluation of CTX-M steady-state mRNA, mRNA half-life and protein production in various STs ofEscherichia coli

Author(s) -

Chelsie N. Geyer,

Randal C. Fowler,

James R. Johnson,

Brian Johnston,

Scott J. Weissman,

Peter M. Hawkey,

Nancy D. Hanson

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv388

Subject(s) - messenger rna , escherichia coli , tazobactam , piperacillin/tazobactam , biology , microbiology and biotechnology , protein biosynthesis , piperacillin , gene , bacteria , biochemistry , genetics , pseudomonas aeruginosa

High levels of β-lactamase production can impact treatment with a β-lactam/β-lactamase inhibitor combination. Goals of this study were to: (i) compare the mRNA and protein levels of CTX-M-15- and CTX-M-14-producing Escherichia coli from 18 different STs and 10 different phylotypes; (ii) evaluate the mRNA half-lives and establish a role for chromosomal- and/or plasmid-encoded factors; and (iii) evaluate the zones of inhibition for piperacillin/tazobactam and ceftolozane/tazobactam.

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