Predictors of bacterial resistance usingin vitrodynamic models: area under the concentration–time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration | Zendy

Ele. Strukova | Zendy; Yury A. Portnoy | Zendy; Stephen H. Zinner | Zendy; Alexander A. Firsov | Zendy

Open Access

Predictors of bacterial resistance usingin vitrodynamic models: area under the concentration–time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration

Author(s) -

Ele. Strukova,

Yury A. Portnoy,

Stephen H. Zinner,

Alexander A. Firsov

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv387

Subject(s) - ciprofloxacin , minimum inhibitory concentration , pseudomonas aeruginosa , mutant , microbiology and biotechnology , antibiotics , chemistry , minimum bactericidal concentration , in vitro , antimicrobial , biology , bacteria , biochemistry , genetics , gene

To examine the predictive power of the ratios of the 24 h AUC (AUC24) to the mutant prevention concentration (MPC) and the MIC, the selection of ciprofloxacin-resistant mutants of Pseudomonas aeruginosa was studied in an in vitro dynamic model.

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