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To examine the predictive power of the ratios of the 24 h AUC (AUC24) to the mutant prevention concentration (MPC) and the MIC, the selection of ciprofloxacin-resistant mutants of Pseudomonas aeruginosa was studied in an in vitro dynamic model.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Predictors of bacterial resistance using<i>in vitro</i>dynamic models: area under the concentration–time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration

Predictors of bacterial resistance usingin vitrodynamic models: area under the concentration–time curve related to either the minimum inhibitory or mutant prevention antibiotic concentration