Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1 | Zendy

Roger Badía | Zendy; Guillem Angulo | Zendy; Eva RiveiraMuñoz | Zendy; Maria Pujantell | Zendy; Teresa Puig | Zendy; Cristina M. Ramírez | Zendy; Javier TorresTorronteras | Zendy; Ramón Martí | Zendy; Eduardo Pauls | Zendy; Bonaventura Clotet | Zendy; Ester Ballana | Zendy; José A. Esté | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

Author(s) -

Roger Badía,

Guillem Angulo,

Eva RiveiraMuñoz,

Maria Pujantell,

Teresa Puig,

Cristina M. Ramírez,

Javier TorresTorronteras,

Ramón Martí,

Eduardo Pauls,

Bonaventura Clotet,

Ester Ballana,

José A. Esté

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv363

Subject(s) - samhd1 , cyclin dependent kinase 6 , cyclin dependent kinase , herpes simplex virus , virology , kinase , cyclin d3 , biology , palbociclib , cell cycle , cyclin , microbiology and biotechnology , virus , biochemistry , cell , rna , genetics , reverse transcriptase , metastatic breast cancer , cancer , breast cancer , gene

Sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) has been shown to restrict retroviruses and DNA viruses by decreasing the pool of intracellular deoxynucleotides. In turn, SAMHD1 is controlled by cyclin-dependent kinases (CDK) that regulate the cell cycle and cell proliferation. Here, we explore the effect of CDK6 inhibitors on the replication of herpes simplex virus type 1 (HSV-1) in primary monocyte-derived macrophages (MDM).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research