Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity? | Zendy

PierreAndré Billat | Zendy; JeanBaptiste Woillard | Zendy; Marie Essig | Zendy; FrançoisLudovic Sauvage | Zendy; Nicolas Picard | Zendy; Sophie Alain | Zendy; Michael Neely | Zendy; Pierre Marquet | Zendy; Franck SaintMarcoux | Zendy

Open Access

Plasma and intracellular exposure to ganciclovir in adult renal transplant recipients: is there an association with haematological toxicity?

Author(s) -

PierreAndré Billat,

JeanBaptiste Woillard,

Marie Essig,

FrançoisLudovic Sauvage,

Nicolas Picard,

Sophie Alain,

Michael Neely,

Pierre Marquet,

Franck SaintMarcoux

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv342

Subject(s) - ganciclovir , pharmacokinetics , neutropenia , toxicity , pharmacology , medicine , dosing , valganciclovir , population , absolute neutrophil count , immunology , human cytomegalovirus , virus , environmental health

Ganciclovir is the most widely used treatment for cytomegalovirus infections. However, neutropenia is a frequent associated adverse effect leading to a decrease in the ganciclovir dose or discontinuation of the therapy, thereby favouring viral resistance. In the present study, the objectives were: (i) to describe the pharmacokinetics of blood and intracellular ganciclovir and its metabolites; and (ii) to explore the relationship between exposure to ganciclovir and/or its metabolites and evolution of the neutrophil count under treatment.

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