Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins | Zendy

Xiaoxi Lu | Zendy; Ting Chan | Zendy; Chenghao Xu | Zendy; Ling Zhu | Zendy; Qi Zhou | Zendy; Kade D. Roberts | Zendy; HakKim Chan | Zendy; Jian Li | Zendy; Fanfan Zhou | Zendy

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Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

Author(s) -

Xiaoxi Lu,

Ting Chan,

Chenghao Xu,

Ling Zhu,

Qi Zhou,

Kade D. Roberts,

HakKim Chan,

Jian Li,

Fanfan Zhou

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv340

Subject(s) - oligopeptide , transporter , symporter , polymyxin , chemistry , biology , bacteria , biochemistry , gene , peptide , genetics

Polymyxins are a last-line therapy to treat MDR Gram-negative bacterial infections. Nephrotoxicity is the dose-limiting factor for polymyxins and recent studies demonstrated significant accumulation of polymyxins in renal tubular cells. However, little is known about the mechanism of polymyxin uptake into these cells. Oligopeptide transporter 2 (PEPT2) is a solute carrier transporter (SLC) expressed at the apical membrane of renal proximal tubular cells and facilitates drug reabsorption in the kidney. In this study, we examined the role of PEPT2 in polymyxin uptake into renal tubular cells.

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