Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization | Zendy

Indrani Mukhopadhya | Zendy; Graeme I. Murray | Zendy; Susan A. Berry | Zendy; John F. Thomson | Zendy; Bruce Frank | Zendy; Garry Gwozdz | Zendy; Julia Makinde | Zendy; Robin J. Shattock | Zendy; Charles Kelly | Zendy; Francesco Iannelli | Zendy; Gianni Pozzi | Zendy; Emad ElOmar | Zendy; Georgina L. Hold | Zendy; Karolin Hijazi | Zendy

Open Access

Drug transporter gene expression in human colorectal tissue and cell lines: modulation with antiretrovirals for microbicide optimization

Author(s) -

Indrani Mukhopadhya,

Graeme I. Murray,

Susan A. Berry,

John F. Thomson,

Bruce Frank,

Garry Gwozdz,

Julia Makinde,

Robin J. Shattock,

Charles Kelly,

Francesco Iannelli,

Gianni Pozzi,

Emad ElOmar,

Georgina L. Hold,

Karolin Hijazi

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv335

Subject(s) - darunavir , gene expression , colorectal cancer , biology , medicine , microbicide , pharmacology , immunology , gene , cancer , genetics , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy

The objectives of this study were to comprehensively assess mRNA expression of 84 drug transporters in human colorectal biopsies and six representative cell lines, and to investigate the alteration of drug transporter gene expression after exposure to three candidate microbicidal antiretroviral (ARV) drugs (tenofovir, darunavir and dapivirine) in the colorectal epithelium. The outcome of the objectives informs development of optimal ARV-based microbicidal formulations for prevention of HIV-1 infection.

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