NLF20: an antimicrobial peptide with therapeutic potential against invasivePseudomonas aeruginosainfection | Zendy

Praveen Papareddy | Zendy; Gopinath Kasetty | Zendy; Martina Kalle | Zendy; Ravi K. V. Bhongir | Zendy; Matthias Mörgelin | Zendy; Artur Schmidtchen | Zendy; Martin Malmsten | Zendy

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NLF20: an antimicrobial peptide with therapeutic potential against invasivePseudomonas aeruginosainfection

Author(s) -

Praveen Papareddy,

Gopinath Kasetty,

Martina Kalle,

Ravi K. V. Bhongir,

Matthias Mörgelin,

Artur Schmidtchen,

Martin Malmsten

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv322

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , antimicrobial , antimicrobial peptides , candida albicans , biology , peptide , bacteria , biochemistry , genetics

Increasing resistance to antibiotics makes antimicrobial peptides interesting as novel therapeutics. Here, we report on studies of the peptide NLF20 (NLFRKLTHRLFRRNFGYTLR), corresponding to an epitope of the D helix of heparin cofactor II (HCII), a plasma protein mediating bacterial clearance.

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