Population pharmacokinetics of rifampicin and 25-deacetyl-rifampicin in healthy Asian adults | Zendy

KokYong Seng | Zendy; KimHor Hee | Zendy; GaikHong Soon | Zendy; Nicholas Chew | Zendy; Saye Khoo | Zendy; Lawrence Lee | Zendy

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Population pharmacokinetics of rifampicin and 25-deacetyl-rifampicin in healthy Asian adults

Author(s) -

KokYong Seng,

KimHor Hee,

GaikHong Soon,

Nicholas Chew,

Saye Khoo,

Lawrence Lee

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv268

Subject(s) - rifampicin , pharmacokinetics , pharmacology , population , volume of distribution , isoniazid , metabolite , nonmem , medicine , tuberculosis , pathology , environmental health

Rifampicin is a first-line anti-TB drug. The objectives of this analysis were to evaluate the population pharmacokinetics of rifampicin and its partly active metabolite, 25-deacetyl-rifampicin, with and without isoniazid, and to identify covariates that may explain variability in their disposition under steady-state conditions.

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