A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants | Zendy

David D. Khan | Zendy; Pernilla Lagerbäck | Zendy; Sha Cao | Zendy; Ulrika Lustig | Zendy; Elisabet I. Nielsen | Zendy; Otto Cars | Zendy; Diarmaid Hughes | Zendy; Dan I. Andersson | Zendy; Lena E. Friberg | Zendy

Open Access

A mechanism-based pharmacokinetic/pharmacodynamic model allows prediction of antibiotic killing from MIC values for WT and mutants

Author(s) -

David D. Khan,

Pernilla Lagerbäck,

Sha Cao,

Ulrika Lustig,

Elisabet I. Nielsen,

Otto Cars,

Diarmaid Hughes,

Dan I. Andersson,

Lena E. Friberg

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv233

Subject(s) - pharmacodynamics , antibiotics , pharmacokinetics , microbiology and biotechnology , mutant , pharmacology , chemistry , medicine , biology , biochemistry , gene

In silico pharmacokinetic/pharmacodynamic (PK/PD) models can be developed based on data from in vitro time-kill experiments and can provide valuable information to guide dosing of antibiotics. The aim was to develop a mechanism-based in silico model that can describe in vitro time-kill experiments of Escherichia coli MG1655 WT and six isogenic mutants exposed to ciprofloxacin and to identify relationships that may be used to simplify future characterizations in a similar setting.

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