Induced tigecycline resistance inStreptococcus pneumoniaemutants reveals mutations in ribosomal proteins and rRNA | Zendy

Andréanne Lupien | Zendy; Hélène Gingras | Zendy; Philippe Leprohon | Zendy; Marc Ouellette | Zendy

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Induced tigecycline resistance inStreptococcus pneumoniaemutants reveals mutations in ribosomal proteins and rRNA

Author(s) -

Andréanne Lupien,

Hélène Gingras,

Philippe Leprohon,

Marc Ouellette

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv211

Subject(s) - tigecycline , biology , microbiology and biotechnology , mutant , efflux , ribosomal rna , streptococcus pneumoniae , tetracycline , genetics , gene , antibiotics

Tigecycline is a broad-spectrum antibiotic acting at the level of the 30S ribosomal subunit to inhibit translation. While Streptococcus pneumoniae remains susceptible to tigecycline, resistance is beginning to emerge in some species and mainly involves efflux or mutations in ribosome constituents. We describe here the characterization of S. pneumoniae mutants selected for resistance to tigecycline.

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