Whole-genome analysis of an oxacillin-susceptible CC80mecA-positiveStaphylococcus aureusclinical isolate: insights into the mechanisms of cryptic methicillin resistance | Zendy

Artur J. Sabat | Zendy; Spyros Pournaras | Zendy; Viktoria Akkerboom | Zendy; Athanassios Tsakris | Zendy; Hajo Grundmann | Zendy; Alexander W. Friedrich | Zendy

Open Access

Whole-genome analysis of an oxacillin-susceptible CC80mecA-positiveStaphylococcus aureusclinical isolate: insights into the mechanisms of cryptic methicillin resistance

Author(s) -

Artur J. Sabat,

Spyros Pournaras,

Viktoria Akkerboom,

Athanassios Tsakris,

Hajo Grundmann,

Alexander W. Friedrich

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv210

Subject(s) - derepression , plasmid , sccmec , biology , staphylococcus aureus , microbiology and biotechnology , penicillin , gene , transposase , repressor , repressor lexa , genome , genetics , transposable element , methicillin resistant staphylococcus aureus , bacteria , antibiotics , gene expression , psychological repression

The mec and bla systems, among other genetic factors, are critical in regulating the expression of methicillin resistance in Staphylococcus aureus. We examined by WGS a naturally occurring oxacillin-susceptible mecA-positive S. aureus isolate to identify the mechanism conferring oxacillin susceptibility.

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