High prevalence of azole resistance inAspergillus fumigatusisolates from high-risk patients | Zendy

Jori Führen | Zendy; W. Sebastiaan Voskuil | Zendy; C. H. E. Boel | Zendy; P. J. A. Haas | Zendy; Ferry Hagen | Zendy; Jacques F. Meis | Zendy; Johannes G. Kusters | Zendy

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High prevalence of azole resistance inAspergillus fumigatusisolates from high-risk patients

Author(s) -

Jori Führen,

W. Sebastiaan Voskuil,

C. H. E. Boel,

P. J. A. Haas,

Ferry Hagen,

Jacques F. Meis,

Johannes G. Kusters

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv177

Subject(s) - voriconazole , aspergillus fumigatus , posaconazole , itraconazole , aspergillosis , typing , biology , microbiology and biotechnology , azole , population , incidence (geometry) , drug resistance , medicine , immunology , antifungal , physics , environmental health , optics

Aspergillus fumigatus is the leading cause of invasive aspergillosis. Adequate treatment is complicated by an increase in azole resistance. Here, the incidence of voriconazole, posaconazole and itraconazole resistance in clinical isolates from high-risk patients from either the haematology ward or the ICU of the University Medical Center Utrecht in the period 2011-13 is analysed. Putative clonality of resistant strains was tested through cyp51A and microsatellite typing.

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