Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors | Zendy

Alina Iulia Chiriac | Zendy; Florian Kloß | Zendy; Jonas Krämer | Zendy; Cuong Vuong | Zendy; Christian Hertweck | Zendy; HansGeorg Sahl | Zendy

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Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors

Author(s) -

Alina Iulia Chiriac,

Florian Kloß,

Jonas Krämer,

Cuong Vuong,

Christian Hertweck,

HansGeorg Sahl

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv161

Subject(s) - dna gyrase , topoisomerase iv , topoisomerase , biology , novobiocin , microbiology and biotechnology , dna , anaerobic bacteria , mechanism of action , periplasmic space , biochemistry , bacteria , antibiotics , escherichia coli , gene , genetics , in vitro

The spread of MDR bacteria represents a serious threat to human society and novel antibiotic drugs, preferably from new chemical classes, are urgently needed. Closthioamide was isolated from the strictly anaerobic bacterium Clostridium cellulolyticum and belongs to a new class of natural products, the polythioamides. Here, we investigated the antimicrobial activity and mechanism of action of closthioamide.

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