Identification of novel mutations associated with clofazimine resistance inMycobacterium tuberculosis: Table 1. | Zendy

Shuo Zhang | Zendy; Jiazhen Chen | Zendy; Peng Cui | Zendy; Wanliang Shi | Zendy; Wenhong Zhang | Zendy; Ying Zhang | Zendy

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Identification of novel mutations associated with clofazimine resistance inMycobacterium tuberculosis: Table 1.

Author(s) -

Shuo Zhang,

Jiazhen Chen,

Peng Cui,

Wanliang Shi,

Wenhong Zhang,

Ying Zhang

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv150

Subject(s) - cycloserine , biology , mutant , genetics , mycobacterium tuberculosis , microbiology and biotechnology , gene , mutation , tuberculosis , medicine , antibiotics , pathology

Although clofazimine has been traditionally used to treat leprosy, there is recent interest in using clofazimine for the treatment of MDR-TB and drug-susceptible TB. However, the mechanisms of resistance to clofazimine are poorly understood. Here, we investigated the molecular basis of clofazimine resistance using resistant mutants isolated in vitro.

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