A UPLC-MS-MS method for the simultaneous quantification of first-line antituberculars in plasma and in PBMCs | Zendy

Lorena Baietto | Zendy; Andrea Calcagno | Zendy; Ilaria Motta | Zendy; Katia Baruffi | Zendy; Viviana Poretti | Zendy; Giovanni Di Perri | Zendy; Stefano Bonora | Zendy; Antonio D’Avolio | Zendy

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A UPLC-MS-MS method for the simultaneous quantification of first-line antituberculars in plasma and in PBMCs

Author(s) -

Lorena Baietto,

Andrea Calcagno,

Ilaria Motta,

Katia Baruffi,

Viviana Poretti,

Giovanni Di Perri,

Stefano Bonora,

Antonio D’Avolio

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv148

Subject(s) - pyrazinamide , ethambutol , cmax , pharmacokinetics , rifampicin , isoniazid , pharmacology , therapeutic drug monitoring , chemistry , peripheral blood mononuclear cell , medicine , chromatography , tuberculosis , antibiotics , pathology , biochemistry , in vitro

TB is currently the second cause of death among patients affected with infectious diseases. Quantification of drug levels in plasma and in cells where Mycobacterium tuberculosis persists and grows may be useful in understanding the appropriateness of dosage regimens. We report a new and fully validated chromatographic method to quantify first-line antituberculars in plasma and PBMCs. The method was used for plasma and cell quantification of antituberculars in patients undergoing treatment with standard oral therapy.

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