Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistancein vivoinCandida albicansorchestrated by multiple genetic alterations | Zendy

Rasmus Krøger Hare | Zendy; Karen Marie Thyssen Astvad | Zendy; Luis Vale Silva | Zendy; Dominique Sanglard | Zendy; René Jørgensen | Zendy; Kristian Fog Nielsen | Zendy; Estella Glintborg Mathiasen | Zendy; Ghazalel Doroudian | Zendy; David Scott Perlin | Zendy; Maiken Cavling Arendrup | Zendy

Open Access

Stepwise emergence of azole, echinocandin and amphotericin B multidrug resistancein vivoinCandida albicansorchestrated by multiple genetic alterations

Author(s) -

Rasmus Krøger Hare,

Karen Marie Thyssen Astvad,

Luis Vale Silva,

Dominique Sanglard,

René Jørgensen,

Kristian Fog Nielsen,

Estella Glintborg Mathiasen,

Ghazalel Doroudian,

David Scott Perlin,

Maiken Cavling Arendrup

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv140

Subject(s) - echinocandin , candida albicans , azole , multiple drug resistance , amphotericin b , biology , microbiology and biotechnology , drug resistance , fluconazole , corpus albicans , in vivo , antifungal , genetics

The objective of this study was to characterize the underlying molecular mechanisms in consecutive clinical Candida albicans isolates from a single patient displaying stepwise-acquired multidrug resistance.

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