Open AccessHigh levels of macrolide resistance-associated mutations inMycoplasma genitaliumwarrant antibiotic susceptibility-guided treatment
Author(s) -
Roel H. T. Nijhuis,
Tim T. Severs,
D. S. J. M. Van der Vegt,
A. A. Van Zwet,
Johannes G. Kusters
Publication year - 2015
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkv136
Subject(s) - mycoplasma genitalium , 23s ribosomal rna , azithromycin , microbiology and biotechnology , moxifloxacin , biology , virology , antibiotics , chlamydia trachomatis , medicine , gene , genetics , ribosome , rna
Mycoplasma genitalium is a sexually transmitted pathogen, and infection with it is usually treated with macrolides. Unfortunately, emerging resistance to the macrolides has been associated with mutations in region V of the 23S rRNA gene. The aim of this retrospective study was to describe the incidence of macrolide resistance-associated mutations in M. genitalium from patients in the Netherlands.