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Combination therapy is an important option in the fight against Gram-negative 'superbugs'. This study systematically investigated bacterial killing and the emergence of polymyxin resistance with polymyxin B and chloramphenicol combinations used against New Delhi metallo-β-lactamase (NDM)-producing MDR Klebsiella pneumoniae.

Synergistic killing of NDM-producing MDRKlebsiella pneumoniaeby two ‘old’ antibiotics—polymyxin B and chloramphenicol