Synergistic killing of NDM-producing MDRKlebsiella pneumoniaeby two ‘old’ antibiotics—polymyxin B and chloramphenicol | Zendy

Nusaibah Abdul Rahim | Zendy; Soon-Ee Cheah | Zendy; Matthew D. Johnson | Zendy; Heidi H. Yu | Zendy; Hanna E. Sidjabat | Zendy; John D. Boyce | Zendy; Mark S. Butler | Zendy; Matthew A. Cooper | Zendy; Jing Fu | Zendy; David L. Paterson | Zendy; Roger L. Nation | Zendy; Phillip J. Bergen | Zendy; Tony Velkov | Zendy; Jian Li | Zendy

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Synergistic killing of NDM-producing MDRKlebsiella pneumoniaeby two ‘old’ antibiotics—polymyxin B and chloramphenicol

Author(s) -

Nusaibah Abdul Rahim,

Soon-Ee Cheah,

Matthew D. Johnson,

Heidi H. Yu,

Hanna E. Sidjabat,

John D. Boyce,

Mark S. Butler,

Matthew A. Cooper,

Jing Fu,

David L. Paterson,

Roger L. Nation,

Phillip J. Bergen,

Tony Velkov,

Jian Li

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv135

Subject(s) - polymyxin , polymyxin b , microbiology and biotechnology , chloramphenicol , klebsiella pneumoniae , antibiotics , biology , multiple drug resistance , drug resistance , escherichia coli , gene , biochemistry

Combination therapy is an important option in the fight against Gram-negative 'superbugs'. This study systematically investigated bacterial killing and the emergence of polymyxin resistance with polymyxin B and chloramphenicol combinations used against New Delhi metallo-β-lactamase (NDM)-producing MDR Klebsiella pneumoniae.

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