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Ex vivo analysis of mitochondrial function may reveal HIV progression and the impact of ART. We propose a mitochondrial and apoptotic in vitro model using Jurkat T cells incubated with plasma. The objectives of this study were to evaluate mitochondrial and apoptotic lesions in this model in relation to HIV progression, and to assess the effect of &gt;1 year of standard non-thymidine-containing therapy.

Mitochondrial and apoptoticin vitromodelling of differential HIV-1 progression and antiretroviral toxicity