Open AccessMitochondrial and apoptoticin vitromodelling of differential HIV-1 progression and antiretroviral toxicity
Author(s) -
Constanza Morén,
M. Carmen Bañó,
Ingrid GonzálezCasacuberta,
Marc CatalánGarcía,
Mariona GuitartMampel,
E. Tobías,
Francesc Cardellach,
Enric Pedrol,
Joaquim Peraire,
Francesc Vidal,
Peré Domingo,
Òscar Miró,
Josep M. Gatell,
Estebán Martínez,
Glòria Garrabou
Publication year - 2015
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkv101
Subject(s) - apoptosis , propidium iodide , mitochondrion , mitochondrial toxicity , western blot , efavirenz , biology , jurkat cells , mfn2 , flow cytometry , microbiology and biotechnology , mitochondrial fusion , annexin , mitochondrial dna , virology , immunology , programmed cell death , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , t cell , genetics , immune system , gene
Ex vivo analysis of mitochondrial function may reveal HIV progression and the impact of ART. We propose a mitochondrial and apoptotic in vitro model using Jurkat T cells incubated with plasma. The objectives of this study were to evaluate mitochondrial and apoptotic lesions in this model in relation to HIV progression, and to assess the effect of >1 year of standard non-thymidine-containing therapy.
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