Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines | Zendy

Haryes A. Funes | Zendy; Ana BlasGarcía | Zendy; Juan V. Esplugues | Zendy; Nadezda Apostolova | Zendy

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Efavirenz alters mitochondrial respiratory function in cultured neuron and glial cell lines

Author(s) -

Haryes A. Funes,

Ana BlasGarcía,

Juan V. Esplugues,

Nadezda Apostolova

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv098

Subject(s) - efavirenz , biology , respiratory system , mitochondrion , extracellular , pharmacology , microbiology and biotechnology , immunology , anatomy , antiretroviral therapy , viral load , human immunodeficiency virus (hiv)

The NNRTI efavirenz is among the most widely employed antiretroviral drugs. Although it is considered safe, efavirenz has been linked with several adverse effects including neurological manifestations, which appear in the majority of the patients on efavirenz-containing regimens. The molecular mechanisms responsible for these manifestations are not understood, but mounting evidence points to altered brain bioenergetics.

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