First-line eradication rates comparing two shortened non-bismuth quadruple regimens againstHelicobacter pylori: an open-label, randomized, multicentre clinical trial | Zendy

Antonio Cuadrado | Zendy; José R. Salcines-Caviedes | Zendy; Ainhoa Diaz-Perez | Zendy; Miguel F. Carrascosa | Zendy; María Elena Ochagavia | Zendy; José Luis Fernández-Forcelledo | Zendy; Marta Cobo | Zendy; Pedro Fernández-Gil | Zendy; B. Ayestaran | Zendy; Blanca Sánchez | Zendy; Cristina Campo | Zendy; Javier Llorca | Zendy; Silvia Lorenzo | Zendy; Aitziber Illaro | Zendy

Open Access

First-line eradication rates comparing two shortened non-bismuth quadruple regimens againstHelicobacter pylori: an open-label, randomized, multicentre clinical trial

Author(s) -

Antonio Cuadrado,

José R. Salcines-Caviedes,

Ainhoa Diaz-Perez,

Miguel F. Carrascosa,

María Elena Ochagavia,

José Luis Fernández-Forcelledo,

Marta Cobo,

Pedro Fernández-Gil,

B. Ayestaran,

Blanca Sánchez,

Cristina Campo,

Javier Llorca,

Silvia Lorenzo,

Aitziber Illaro

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv089

Subject(s) - medicine , helicobacter pylori , regimen , metronidazole , gastroenterology , amoxicillin , clarithromycin , omeprazole , urea breath test , adverse effect , intention to treat analysis , randomized controlled trial , breath test , concomitant , surgery , antibiotics , helicobacter pylori infection , microbiology and biotechnology , biology

Helicobacter pylori eradication remains a challenge. Non-bismuth-based quadruple regimens (NBQR) have shown high eradication rates (ER) elsewhere that need to be locally confirmed. The objective of this study was to compare the first-line ER of a hybrid therapy (20 mg of omeprazole twice daily and 1 g of amoxicillin twice daily for 10 days, adding 500 mg of clarithromycin twice daily and 500 mg of metronidazole every 8 h for the last 5 days; OA-OACM) with that of a 10 day concomitant regimen consisting of taking all four drugs twice daily every day (including 500 mg of metronidazole every 12 h; OACM). A 10 day arm with standard triple therapy (OAC; 20 mg of omeprazole/12 h, 1 g of amoxicillin/12 h and 500 mg of clarithromycin/12 h) was included.

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