Bactericidal mode of action of bedaquiline | Zendy

Kiel Hards | Zendy; Jennifer Robson | Zendy; Michael Berney | Zendy; Lisa E. Shaw | Zendy; Dirk Bald | Zendy; Anil Koul | Zendy; Koen Andries | Zendy; Gregory M. Cook | Zendy

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Bactericidal mode of action of bedaquiline

Author(s) -

Kiel Hards,

Jennifer Robson,

Michael Berney,

Lisa E. Shaw,

Dirk Bald,

Anil Koul,

Koen Andries,

Gregory M. Cook

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv054

Subject(s) - bedaquiline , atp synthase , biochemistry , chemistry , respiratory chain , chemiosmosis , biophysics , mitochondrion , biology , mycobacterium tuberculosis , medicine , tuberculosis , pathology , enzyme

It is not fully understood why inhibiting ATP synthesis in Mycobacterium species leads to death in non-replicating cells. We investigated the bactericidal mode of action of the anti-tubercular F1Fo-ATP synthase inhibitor bedaquiline (Sirturo™) in order to further understand the lethality of ATP synthase inhibition.

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