Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates | Zendy

Pyry A. J. Välitalo | Zendy; John N. van den Anker | Zendy; Karel Allegaert | Zendy; Roosmarijn F. W. De Cock | Zendy; Matthijs de Hoog | Zendy; Sinno H. P. Simons | Zendy; Johan W. Mouton | Zendy; Catherijne A. J. Knibbe | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Novel model-based dosing guidelines for gentamicin and tobramycin in preterm and term neonates

Author(s) -

Pyry A. J. Välitalo,

John N. van den Anker,

Karel Allegaert,

Roosmarijn F. W. De Cock,

Matthijs de Hoog,

Sinno H. P. Simons,

Johan W. Mouton,

Catherijne A. J. Knibbe

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv052

Subject(s) - tobramycin , dosing , gentamicin , medicine , term (time) , aminoglycoside , intensive care medicine , antibiotics , pharmacology , microbiology and biotechnology , biology , physics , quantum mechanics

In the heterogeneous group of preterm and term neonates, gentamicin and tobramycin are mainly dosed according to empirical guidelines, after which therapeutic drug monitoring and subsequent dose adaptation are applied. In view of the variety of neonatal guidelines available, the purpose of this study was to evaluate target concentration attainment of these guidelines, and to propose a new model-based dosing guideline for these drugs in neonates.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research