In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections | Zendy

David Lebeaux | Zendy; Véronique LeflonGuibout | Zendy; JeanMarc Ghigo | Zendy; Christophe Beloin | Zendy

Open Access

In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections

Author(s) -

David Lebeaux,

Véronique LeflonGuibout,

JeanMarc Ghigo,

Christophe Beloin

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv044

Subject(s) - microbiology and biotechnology , gentamicin , amikacin , biofilm , vancomycin , antibiotics , enterococcus faecalis , pseudomonas aeruginosa , staphylococcus aureus , enterococcus , bacteria , biology , chemistry , genetics

Treatment of catheter-related bloodstream infections (CRBSI) is hampered by the characteristic tolerance of bacterial biofilms towards antibiotics. Our objective was to study the effect of the combination of antibiotics and the alkaline amino acid l-arginine or the cation chelator EDTA on the bacterial killing of in vitro biofilms formed by an array of clinical strains responsible for CRBSI and representative of epidemiologically relevant bacterial species.

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