Pharmacokinetics of anti-TB drugs in Malawian children: reconsidering the role of ethambutol | Zendy

R. Mlotha | Zendy; David Waterhouse | Zendy; Fraction K. Dzinjalamala | Zendy; Alison Ardrey | Zendy; Elizabeth Molyneux | Zendy; Geraint Davies | Zendy; Stephen A. Ward | Zendy

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Pharmacokinetics of anti-TB drugs in Malawian children: reconsidering the role of ethambutol

Author(s) -

R. Mlotha,

David Waterhouse,

Fraction K. Dzinjalamala,

Alison Ardrey,

Elizabeth Molyneux,

Geraint Davies,

Stephen A. Ward

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv039

Subject(s) - ethambutol , pharmacokinetics , medicine , pharmacology , antibacterial agent , tb treatment , tuberculosis , antibiotics , human immunodeficiency virus (hiv) , virology , rifampicin , microbiology and biotechnology , biology , pathology

Current guidelines for dosing of anti-TB drugs in children advocate higher doses for rifampicin and isoniazid despite limited availability of paediatric data on the pharmacokinetics of these drugs, especially from Africa, where the burden of childhood disease remains high.

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