Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms | Zendy

N Vandevelde | Zendy; Paul M. Tulkens | Zendy; Giulio G. Muccioli | Zendy; Françoise Van Bambeke | Zendy

Open Access

Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms

Author(s) -

N Vandevelde,

Paul M. Tulkens,

Giulio G. Muccioli,

Françoise Van Bambeke

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv032

Subject(s) - biofilm , microbiology and biotechnology , streptococcus pneumoniae , ipratropium , antibiotics , moxifloxacin , pharmacology , chemistry , pharmacodynamics , bacteria , medicine , biology , bronchodilator , pharmacokinetics , asthma , genetics

Bacterial biofilms developing in the bronchial tree of patients experiencing acute exacerbations of chronic bronchitis (AECBs) are suggested to cause relapses and recurrences of the disease because the matrix barrier impairs antibiotic access to the offending organisms. We examined whether bronchodilators could modulate pneumococcal biofilm development and antibiotic action using an in vitro model.

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