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Bacterial biofilms developing in the bronchial tree of patients experiencing acute exacerbations of chronic bronchitis (AECBs) are suggested to cause relapses and recurrences of the disease because the matrix barrier impairs antibiotic access to the offending organisms. We examined whether bronchodilators could modulate pneumococcal biofilm development and antibiotic action using an in vitro model.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Modulation of the activity of moxifloxacin and solithromycin in an <i>in vitro</i> pharmacodynamic model of <i>Streptococcus pneumoniae</i> naive and induced biofilms

Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms