Synergy of chemotherapy and immunotherapy revealed by a genome-scale analysis of murine tuberculosis | Zendy

Rodrigo F. Rodrigues | Zendy; Carlos R. Zárate-Bladés | Zendy; Wendy Martin Rios | Zendy; Luana Silva Soares | Zendy; Patricia Souza | Zendy; Izaíra Tincani Brandão | Zendy; Ana Paula Masson | Zendy; Frederico G. C. Arnoldi | Zendy; Simone G. Ramos | Zendy; Franck Letourneur | Zendy; Sébastien Jacques | Zendy; Nicolas Cagnard | Zendy; Gilles Chiocchia | Zendy; Célio Lopes Silva | Zendy

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Synergy of chemotherapy and immunotherapy revealed by a genome-scale analysis of murine tuberculosis

Author(s) -

Rodrigo F. Rodrigues,

Carlos R. Zárate-Bladés,

Wendy Martin Rios,

Luana Silva Soares,

Patricia Souza,

Izaíra Tincani Brandão,

Ana Paula Masson,

Frederico G. C. Arnoldi,

Simone G. Ramos,

Franck Letourneur,

Sébastien Jacques,

Nicolas Cagnard,

Gilles Chiocchia,

Célio Lopes Silva

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv023

Subject(s) - immunotherapy , tuberculosis , chemotherapy , genome , immunology , medicine , biology , virology , immune system , genetics , pathology , gene

Although TB immunotherapy improves the results of conventional drug treatment, the effects of combining chemotherapy and immunotherapy have never been systematically evaluated. We used a comprehensive lung transcriptome analysis to directly compare the activity of combined chemotherapy and immunotherapy with that of single treatments in a mouse model of TB.

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