Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC | Zendy

Sushmita D. Lahiri | Zendy; Grant K. Walkup | Zendy; James Whiteaker | Zendy; Tiffany Palmer | Zendy; Kathy McCormack | Zendy; M. Angela Tanudra | Zendy; Tory J. Nash | Zendy; Jason Thresher | Zendy; Michele Johnstone | Zendy; Laurie Hajec | Zendy; Stephania Livchak | Zendy; Robert E. McLaughlin | Zendy; Richard A. Alm | Zendy

Open Access

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC

Author(s) -

Sushmita D. Lahiri,

Grant K. Walkup,

James Whiteaker,

Tiffany Palmer,

Kathy McCormack,

M. Angela Tanudra,

Tory J. Nash,

Jason Thresher,

Michele Johnstone,

Laurie Hajec,

Stephania Livchak,

Robert E. McLaughlin,

Richard A. Alm

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv004

Subject(s) - ceftazidime/avibactam , avibactam , ceftazidime , pseudomonas aeruginosa , microbiology and biotechnology , mutant , biology , beta lactamase inhibitors , chemistry , bacteria , biochemistry , antibiotics , gene , genetics

Pseudomonas aeruginosa is an important nosocomial pathogen that can cause a wide range of infections resulting in significant morbidity and mortality. Avibactam, a novel non-β-lactam β-lactamase inhibitor, is being developed in combination with ceftazidime and has the potential to be a valuable addition to the treatment options for the infectious diseases practitioner. We compared the frequency of resistance development to ceftazidime/avibactam in three P. aeruginosa strains that carried derepressed ampC alleles.

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