OXY-2-15, a novel variant showing increased ceftazidime hydrolytic activity | Zendy

R.H.T. Nijhuis | Zendy; Saoussen Oueslati | Zendy; Kaiqian Zhou | Zendy; Ron Bosboom | Zendy; John W. A. Rossen | Zendy; Thierry Naas | Zendy

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OXY-2-15, a novel variant showing increased ceftazidime hydrolytic activity

Author(s) -

R.H.T. Nijhuis,

Saoussen Oueslati,

Kaiqian Zhou,

Ron Bosboom,

John W. A. Rossen,

Thierry Naas

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv002

Subject(s) - ceftazidime , klebsiella oxytoca , microbiology and biotechnology , biology , enterobacteriaceae , escherichia coli , gene , bacteria , biochemistry , genetics , pseudomonas aeruginosa

Klebsiella oxytoca is a member of the family of Enterobacteriaceae and often contains the β-lactamase blaOXY gene. Although this β-lactamase does not naturally hydrolyse ceftazidime, this study describes possible in vivo selection of a clinical K. oxytoca isolate showing increased MICs of ceftazidime.

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