Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance | Zendy

Neang S. Ly | Zendy; Jürgen B. Bulitta | Zendy; Gauri G. Rao | Zendy; Cornelia B. Landersdorfer | Zendy; Patricia N. Holden | Zendy; Alan Forrest | Zendy; Phillip J. Bergen | Zendy; Roger L. Nation | Zendy; Jian Li | Zendy; Brian T. Tsuji | Zendy

Open Access

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

Author(s) -

Neang S. Ly,

Jürgen B. Bulitta,

Gauri G. Rao,

Cornelia B. Landersdorfer,

Patricia N. Holden,

Alan Forrest,

Phillip J. Bergen,

Roger L. Nation,

Jian Li,

Brian T. Tsuji

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku567

Subject(s) - colistin , doripenem , pseudomonas aeruginosa , microbiology and biotechnology , antibiotics , drug resistance , polymyxin , pharmacology , medicine , biology , antibiotic resistance , bacteria , meropenem , genetics

Colistin is an 'old' drug, which is being increasingly utilized due to limited therapeutic options. However, resistance emergence during monotherapy is concerning. Here, our objective was to optimize colistin combinations against Pseudomonas aeruginosa by profiling the time course of synergistic killing and prevention of resistance.

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