Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species | Zendy

Frédéric Lamoth | Zendy; Barbara D. Alexander | Zendy; Praveen R. Juvvadi | Zendy; William J. Steinbach | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species

Author(s) -

Frédéric Lamoth,

Barbara D. Alexander,

Praveen R. Juvvadi,

William J. Steinbach

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku549

Subject(s) - microbiology and biotechnology , biology , paecilomyces , aspergillus terreus , geldanamycin , hsp90 , heat shock protein , biochemistry , botany , gene

Invasive mould infections are associated with a high mortality rate and the emergence of MDR moulds is of particular concern. Calcineurin and its chaperone, the heat shock protein 90 (Hsp90), represent an important pathway for fungal virulence that can be targeted at different levels. We investigated the antifungal activity of compounds directly or indirectly targeting the Hsp90-calcineurin axis against different mould species.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research