Activity of temocillin in a murine model of urinary tract infection due to Escherichia coli producing or not producing the ESBL CTX-M-15 | Zendy

J.-F. Soubirou | Zendy; Benjamín Rossi | Zendy; Camille Couffignal | Zendy; Étienne Ruppé | Zendy; F. Chau | Zendy; Laurent Massias | Zendy; Raphaël Lepeule | Zendy; France Mentré | Zendy; B. Fantin | Zendy

Open Access

Activity of temocillin in a murine model of urinary tract infection due to Escherichia coli producing or not producing the ESBL CTX-M-15

Author(s) -

J.-F. Soubirou,

Benjamín Rossi,

Camille Couffignal,

Étienne Ruppé,

F. Chau,

Laurent Massias,

Raphaël Lepeule,

France Mentré,

B. Fantin

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku542

Subject(s) - imipenem , microbiology and biotechnology , in vivo , escherichia coli , pharmacology , urinary system , regimen , medicine , antibiotics , chemistry , biology , antibiotic resistance , biochemistry , gene

Temocillin is a 6α-methoxy derivative of ticarcillin that is resilient to ESBLs. Prospective data about its in vivo activity remain scarce. Our aims were: (i) to evaluate the activity of temocillin in a urinary tract infection (UTI) model due to ESBL-producing Escherichia coli and compare it with that of imipenem; and (ii) to define in vivo susceptibility breakpoints.

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