New plasmid-mediated aminoglycoside 6′-N-acetyltransferase, AAC(6′)-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate | Zendy

Wanchun Jin | Zendy; Junichi Wachino | Zendy; Kouji Kimura | Zendy; Keiko Yamada | Zendy; Yoshichika Arakawa | Zendy

Open Access

New plasmid-mediated aminoglycoside 6′-N-acetyltransferase, AAC(6′)-Ian, and ESBL, TLA-3, from a Serratia marcescens clinical isolate

Author(s) -

Wanchun Jin,

Junichi Wachino,

Kouji Kimura,

Keiko Yamada,

Yoshichika Arakawa

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku537

Subject(s) - amikacin , serratia marcescens , microbiology and biotechnology , plasmid , biology , enterobacteriaceae , chloramphenicol acetyltransferase , gene , escherichia coli , genetics , antibiotics , reporter gene , gene expression

Enterobacteriaceae clinical isolates showing amikacin resistance (MIC 64 to >256 mg/L) in the absence of 16S rRNA methyltransferase (MTase) genes were found. The aim of this study was to clarify the molecular mechanisms underlying amikacin resistance in Enterobacteriaceae clinical isolates that do not produce 16S rRNA MTases.

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