Up-regulation of silent information regulator 2 (Sir2) is associated with amphotericin B resistance in clinical isolates of Leishmania donovani | Zendy

Bidyut Purkait | Zendy; Ruby Singh | Zendy; Kirti Wasnik | Zendy; Sushmita Das | Zendy; Ashish Kumar | Zendy; Mark J. I. Paine | Zendy; Manas Ranjan Dikhit | Zendy; Dharmendra Singh | Zendy; Abul Hasan Sardar | Zendy; Ayan Kumar Ghosh | Zendy; Pradeep Das | Zendy

Open Access

Up-regulation of silent information regulator 2 (Sir2) is associated with amphotericin B resistance in clinical isolates of Leishmania donovani

Author(s) -

Bidyut Purkait,

Ruby Singh,

Kirti Wasnik,

Sushmita Das,

Ashish Kumar,

Mark J. I. Paine,

Manas Ranjan Dikhit,

Dharmendra Singh,

Abul Hasan Sardar,

Ayan Kumar Ghosh,

Pradeep Das

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku534

Subject(s) - biology , nad+ kinase , apoptosis , efflux , leishmania donovani , microbiology and biotechnology , biochemistry , enzyme , immunology , leishmaniasis , visceral leishmaniasis

Silent information regulator 2 (Sir2) is involved in parasite survival and apoptosis. Here, we aimed to explore the involvement of Sir2 in amphotericin B (AmB) resistance mechanism in Leishmania donovani.

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