Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents | Zendy

Suresh B. Lakshminarayana | Zendy; Tan Bee Huat | Zendy; Paul C. Ho | Zendy; Ujjini H. Manjunatha | Zendy; Véronique Dartois | Zendy; Thomas Dick | Zendy; Srinivasa P. S. Rao | Zendy

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Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents

Author(s) -

Suresh B. Lakshminarayana,

Tan Bee Huat,

Paul C. Ho,

Ujjini H. Manjunatha,

Véronique Dartois,

Thomas Dick,

Srinivasa P. S. Rao

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku457

Subject(s) - pharmacokinetics , potency , pharmacology , bioavailability , in vivo , drug discovery , drug , metabolic stability , chemistry , in vitro , medicine , biology , biochemistry , microbiology and biotechnology

The discovery and development of TB drugs has met limited success, with two new drugs approved over the last 40 years. Part of the difficulty resides in the lack of well-established in vitro or in vivo targets of potency and physicochemical and pharmacokinetic parameters. In an attempt to benchmark and compare such properties for anti-TB agents, we have experimentally determined and compiled these parameters for 36 anti-TB compounds, using standardized and centralized assays, thus ensuring direct comparability across drugs and drug classes.

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