Imaging the distribution of polymyxins in the kidney | Zendy

Bo Hyon Yun | Zendy; M. A. K. Azad | Zendy; J. Wang | Zendy; Roger L. Nation | Zendy; Philip E. Thompson | Zendy; Kade D. Roberts | Zendy; Tony Velkov | Zendy; Jian Li | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Imaging the distribution of polymyxins in the kidney

Author(s) -

Bo Hyon Yun,

M. A. K. Azad,

J. Wang,

Roger L. Nation,

Philip E. Thompson,

Kade D. Roberts,

Tony Velkov,

Jian Li

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku441

Subject(s) - nephrotoxicity , polymyxin b , polymyxin , kidney , colistin , immunostaining , biology , chemistry , pharmacology , microbiology and biotechnology , antibiotics , immunology , endocrinology , immunohistochemistry

Dose-limiting nephrotoxicity remains the Achilles' heel of polymyxin B and polymyxin E (also known as colistin), which are important last-line antibiotics used against infections caused by MDR Gram-negative 'superbugs'. An understanding of the mechanisms of nephrotoxicity, including renal tissue distribution, is crucial for the development of safer polymyxin lipopeptide antibiotics. This is the first study to visualize the kidney distribution of polymyxin B using a mouse nephrotoxicity model and in situ immunostaining of kidney sections.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research