Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study | Zendy

Emmanuelle Cambau | Zendy; Miguel Viveiros | Zendy; Diana Machado | Zendy; Laurent Raskine | Zendy; C. Ritter | Zendy; Enrico Tortoli | Zendy; V. Matthys | Zendy; Sven Hoffner | Zendy; Elvira Richter | Zendy; María de Toro | Zendy; Daniela María Cirillo | Zendy; Dick van Soolingen | Zendy; Erik C. Böttger | Zendy

Open Access

Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study

Author(s) -

Emmanuelle Cambau,

Miguel Viveiros,

Diana Machado,

Laurent Raskine,

C. Ritter,

Enrico Tortoli,

V. Matthys,

Sven Hoffner,

Elvira Richter,

María de Toro,

Daniela María Cirillo,

Dick van Soolingen,

Erik C. Böttger

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku438

Subject(s) - medicine , drug resistance , drug , tb treatment , pharmacology , tuberculosis , biology , genetics , pathology

Treatment outcome of MDR-TB is critically dependent on the proper use of second-line drugs as per the result of in vitro drug susceptibility testing (DST). We aimed to establish a standardized DST procedure based on quantitative determination of drug resistance and compared the results with those of genotypes associated with drug resistance.

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