Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa | Zendy

Vanessa E. Rees | Zendy; Jürgen B. Bulitta | Zendy; Roger L. Nation | Zendy; Brian T. Tsuji | Zendy; Fritz Sörgel | Zendy; Cornelia B. Landersdorfer | Zendy

Open Access

Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa

Author(s) -

Vanessa E. Rees,

Jürgen B. Bulitta,

Roger L. Nation,

Brian T. Tsuji,

Fritz Sörgel,

Cornelia B. Landersdorfer

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku437

Subject(s) - ciprofloxacin , efflux , pseudomonas aeruginosa , microbiology and biotechnology , bacteria , antibiotics , minimum inhibitory concentration , pseudomonas , chemistry , pharmacology , biology , biochemistry , genetics

For fluoroquinolones, the area under the free plasma concentration-time curve divided by the MIC (fAUC/MIC) best predicts bacterial killing in mice and outcomes in patients. However, it is unknown whether the shape of the antibiotic concentration profile affects resistance emergence. Our objective was to compare killing and resistance between ciprofloxacin concentration profiles with different shapes at the same fAUC/MIC and identify the durations of ciprofloxacin exposure that minimize resistance emergence.

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