Identification of optimal renal dosage adjustments for high-dose extended-infusion cefepime dosing regimens in hospitalized patients | Zendy

Evan J. Zasowski | Zendy; Christopher M. Bland | Zendy; Vincent H. Tam | Zendy; Thomas P. Lodise | Zendy

Open Access

Identification of optimal renal dosage adjustments for high-dose extended-infusion cefepime dosing regimens in hospitalized patients

Author(s) -

Evan J. Zasowski,

Christopher M. Bland,

Vincent H. Tam,

Thomas P. Lodise

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku435

Subject(s) - dosing , renal function , cefepime , medicine , pharmacokinetics , population , regimen , pharmacodynamics , pharmacology , confidence interval , urology , chemistry , antibiotics , biochemistry , environmental health , antibiotic resistance , imipenem

The objective of this study was to identify optimal renal dose adjustments for 2 g of cefepime every 8 h as a 3 h infusion where the probability of target attainment was optimized and drug accumulation was minimal.

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