The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations | Zendy

Ruth Bowness | Zendy; Martin J. Boeree | Zendy; Rob E. Aarnoutse | Zendy; Rodney Dawson | Zendy; Andreas H. Diacon | Zendy; Chacha Mangu | Zendy; Norbert Heinrich | Zendy; Nyanda Elias Ntinginya | Zendy; Anke Kohlenberg | Zendy; Bariki Mtafya | Zendy; Patrick Phillips | Zendy; Andrea Rachow | Zendy; Georgette Plemper van Balen | Zendy; Stephen H. Gillespie | Zendy

Open Access

The relationship between Mycobacterium tuberculosis MGIT time to positivity and cfu in sputum samples demonstrates changing bacterial phenotypes potentially reflecting the impact of chemotherapy on critical sub-populations

Author(s) -

Ruth Bowness,

Martin J. Boeree,

Rob E. Aarnoutse,

Rodney Dawson,

Andreas H. Diacon,

Chacha Mangu,

Norbert Heinrich,

Nyanda Elias Ntinginya,

Anke Kohlenberg,

Bariki Mtafya,

Patrick Phillips,

Andrea Rachow,

Georgette Plemper van Balen,

Stephen H. Gillespie

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku415

Subject(s) - rifampicin , mycobacterium tuberculosis , sputum , tuberculosis , microbiology and biotechnology , liquid culture , biology , population , phenotype , antibiotics , medicine , immunology , pathology , genetics , environmental health , botany , gene

The relationship between cfu and Mycobacterial Growth Indicator Tube (MGIT) time to positivity (TTP) is uncertain. We attempted to understand this relationship and create a mathematical model to relate these two methods of determining mycobacterial load.

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