Concomitant occurrence of itraconazole-resistant and -susceptible strains of Aspergillus fumigatus in routine cultures
Author(s) -
Suhail Ahmad,
Leena Joseph,
Ferry Hagen,
Jacques F. Meis,
Ziauddin Khan
Publication year - 2014
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dku410
Subject(s) - itraconazole , aspergillus fumigatus , posaconazole , microbiology and biotechnology , biology , broth microdilution , etest , drug resistance , voriconazole , triazole , minimum inhibitory concentration , chemistry , antibiotics , antifungal , organic chemistry
Resistance to triazoles in Aspergillus fumigatus has emerged in several countries and is usually mediated by mutations in the cyp51A gene. We determined the presence of both itraconazole-susceptible and -resistant A. fumigatus in routine cultures isolated from environmental and clinical samples.
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