Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg− mothers: a systematic review and meta-analysis | Zendy

Maria Machaira | Zendy; Vassiliki Papaevangelou | Zendy; Evridiki K. Vouloumanou | Zendy; Giannoula S. Tansarli | Zendy; Matthew E. Falagas | Zendy

Open Access

Hepatitis B vaccine alone or with hepatitis B immunoglobulin in neonates of HBsAg+/HBeAg− mothers: a systematic review and meta-analysis

Author(s) -

Maria Machaira,

Vassiliki Papaevangelou,

Evridiki K. Vouloumanou,

Giannoula S. Tansarli,

Matthew E. Falagas

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku404

Subject(s) - medicine , hbsag , hbeag , hepatitis b vaccine , hepatitis b , immunization , virology , immunology , antibody , hepatitis b virus , vaccination , virus

The cost-effectiveness of augmenting immunization against hepatitis B infection with hepatitis B immunoglobulin (HBIG) remains controversial, particularly for the subpopulation of babies of HBsAg+/HBeAg- mothers that are considered as low-infective. We aimed to evaluate the effectiveness of vaccine alone compared with vaccine plus HBIG for the immunization of babies of HBsAg+/HBeAg- mothers.

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