Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability | Zendy

Anne Makena | Zendy; Jürgen Brem | Zendy; Inga Pfeffer | Zendy; Rebecca E. J. Geffen | Zendy; Sarah E. Wilkins | Zendy; Hanna Tarhonskaya | Zendy; Emily Flashman | Zendy; Lynette Phee | Zendy; David W. Wareham | Zendy; Christopher J. Schofield | Zendy

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Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability

Author(s) -

Anne Makena,

Jürgen Brem,

Inga Pfeffer,

Rebecca E. J. Geffen,

Sarah E. Wilkins,

Hanna Tarhonskaya,

Emily Flashman,

Lynette Phee,

David W. Wareham,

Christopher J. Schofield

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku403

Subject(s) - new delhi , antibiotics , microbiology and biotechnology , biology , genetics , medicine , metropolitan area , pathology

Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activity despite being located outside the active site. This study compares the biochemical properties of seven clinically reported NDM variants.

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