The combination of ceftaroline plus daptomycin allows for therapeutic de-escalation and daptomycin sparing against MRSA | Zendy

Katie E. Barber | Zendy; Brian J. Werth | Zendy; Michael J. Rybak | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The combination of ceftaroline plus daptomycin allows for therapeutic de-escalation and daptomycin sparing against MRSA

Author(s) -

Katie E. Barber,

Brian J. Werth,

Michael J. Rybak

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku378

Subject(s) - daptomycin , medicine , pharmacodynamics , pharmacokinetics , pharmacology , antibiotics , cephalosporin , staphylococcus aureus , microbiology and biotechnology , vancomycin , bacteria , biology , genetics

We previously demonstrated that ceftaroline enhances daptomycin against MRSA in vitro. However, prolonged combination therapy is clinically undesirable and possibly unnecessary. The purpose of this study was to determine if this combination could be de-escalated to a single agent without compromising efficacy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research