Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus | Zendy

Joana RochaPereira | Zendy; Dirk Jochmans | Zendy; Johan Neyts | Zendy

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Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus

Author(s) -

Joana RochaPereira,

Dirk Jochmans,

Johan Neyts

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku363

Subject(s) - norovirus , murine norovirus , virology , transmission (telecommunications) , medicine , outbreak , infectious dose , nucleoside analogue , virus , biology , nucleoside , biochemistry , electrical engineering , engineering

Norovirus outbreaks of acute gastroenteritis are highly prevalent, extensive and can disturb the functioning of health institutions, leading to the closure of hospital wards and causing life-threatening infections in long-term care facilities. There is no vaccine available; hence there is a pressing need for antivirals for the treatment (in immunodeficient patients) and prophylaxis of norovirus infections. We explored in a mouse model whether an inhibitor of norovirus replication can prevent/reduce transmission of the virus.

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