Strain-specific antiviral activity of iminosugars against human influenza A viruses | Zendy

Saira Hussain | Zendy; Joanna L. Miller | Zendy; David J. Harvey | Zendy; Yong Q. Gu | Zendy; Peter B. Rosenthal | Zendy; Nicole Zitzmann | Zendy; John W. McCauley | Zendy

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Strain-specific antiviral activity of iminosugars against human influenza A viruses

Author(s) -

Saira Hussain,

Joanna L. Miller,

David J. Harvey,

Yong Q. Gu,

Peter B. Rosenthal,

Nicole Zitzmann,

John W. McCauley

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku349

Subject(s) - iminosugar , virology , influenza a virus , strain (injury) , glucosidases , human influenza , microbiology and biotechnology , biology , chemistry , enzyme , virus , medicine , biochemistry , covid-19 , infectious disease (medical specialty) , disease , anatomy , pathology

Drugs that target host cell processes can be employed to complement drugs that specifically target viruses, and iminosugar compounds that inhibit host α-glucosidases have been reported to show antiviral activity against multiple viruses. Here the effect and mechanism of two iminosugar α-glucosidase inhibitors, N-butyl-deoxynojirimycin (NB-DNJ) and N-nonyl-deoxynojirimycin (NN-DNJ), on human influenza A viruses was examined.

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