Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficile | Zendy

Michael J. Aldape | Zendy; Dustin Heeney | Zendy; Amy E. Bryant | Zendy; Dennis L. Stevens | Zendy

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Tigecycline suppresses toxin A and B production and sporulation in Clostridium difficile

Author(s) -

Michael J. Aldape,

Dustin Heeney,

Amy E. Bryant,

Dennis L. Stevens

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku325

Subject(s) - tigecycline , microbiology and biotechnology , clostridium difficile , toxin , clostridium difficile toxin a , clostridium difficile toxin b , biology , antibiotics

Clostridium difficile infection (CDI) is mediated by potent extracellular toxins and is spread largely via bacterial spores. We and others have shown that some antibiotics stimulate C. difficile toxin production in a strain-specific manner; however, the effects of newer anti-C. difficile antibiotics on this process remain to be investigated.

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